Rational catalyst design is the holy grail of modern catalysis, which requires a thorough understanding of structure–performance relationships. Microscopy and spectroscopy both play a pivotal role in the study of these relationships through the visualization of the diffusive species, such as reaction products, and the pore network of a catalyst particle . Direct relations can be investigated via spatial correlation of complementary imaging techniques, which has been proven to be a valuable tool for biological samples . The rapid developments in 3D super-resolution fluorescence microscopy, 3D X-ray microscopy, and 3D electron microscopy techniques hold great promise for the development of correlative microscopy to study inorganic materials [3–5]. The aim of this research project is the development and use of correlative microscopy to study structure–performance relationships in single porous catalyst particles.